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A Healthy Gamble for Cystic Fibrosis

Ten years ago, Dr. Robert Beall was worried that an opportunity to develop new drugs for cystic fibrosis patients was being squandered. The faulty gene that causes the inherited disease had been discovered nearly a decade before. Researchers had made great strides understanding the biological defect, which leads to progressively worse lung disease.

But aside from failed attempts at gene therapy, no drug companies had joined the quest for new treatments. "We were frustrated," says Beall, president of the Cystic Fibrosis Foundation. "Companies only wanted blockbuster drugs, and no one was willing to spend money on cystic fibrosis," a disease that afflicts just 35,000 people in the U.S. But rather than fuming, "I took the biggest gamble I ever made," Beall recalls. If the pharmaceutical industry wouldn't try to develop cystic fibrosis (CF) drugs on its own, the foundation would pay it to do so.

A New Funding Model

Until then, foundations devoted to specific diseases mainly used the donations they received to provide care and support for patients or to fund basic university research that usually didn't focus on drug development. Beall made the controversial decision to get private industry involved. Since then, the Cystic Fibrosis Foundation has handed drug companies $175 million, a figure that could rise to nearly $300 million if the companies reach certain milestones in the assorted projects.

It has taken plenty of patience, but now the bold move is beginning to pay off. In late March, a partner named Vertex Pharmaceuticals (VRTX) released results showing, for the first time ever, that a drug could actually fix the biochemical flaw in some CF patients. "When they showed us the data, it was one of the happiest days of my life," says Beall.

Yet there could be disappointments ahead. The experimental Vertex drug has only been given to 16 patients for just 14 days, so its long-term safety is unknown. In addition, its potential benefit only applies to a small fraction of CF patients. But the results "mean to me that we do have hope of working directly with the abnormal protein to treat the disease," says Dr. Frank Accurso, director of the CF center at the University of Colorado School of Medicine in Denver. Even better, Vertex has developed a second experimental drug that may treat a larger group of CF patients.

Assay Assist

The results, scientists say, prove Beall's gamble was the right move, one that has since been copied by other nonprofit groups. But when Beall first decided to partner with industry, the response was not overwhelming. "I called up five or six companies, but only two even returned my phone call," he recalls. Big Pharma wants drugs that can be used by millions of people, not tens of thousands. Then Beall heard about a company named Aurora Biosciences in San Diego. Its claim to fame: creating biological tests, known as assays, that could be used to screen hundreds of thousands of chemicals to look for drug candidates.

At the time, "we didn't even know if it was possible to make an assay" to look for drugs to treat CF, Beall explains. CF patients have a defect in their cells. Normal cells produce proteins that create channels in their membranes, or outer shells, that enable important substances to enter and leave. Think of them like the gates of a walled city. But for CF sufferers, the gate for chloride ions and other molecules is missing or defective, causing a variety of symptoms. The most dire is that their lungs produce thick mucus that impairs breathing and fosters infections that damage the lungs. The lungs lose function at an average rate of about 2% per year. "So by age 30, patients have lost 60% of lung function," says Beall. Life expectancy has been increasing thanks to treatments for the mucus and infections, but the average sufferer still succumbs before age 40.

Rock and Roll Casino.com

There are many good Internet magazines called E-zines that offer gambling information, Some of these offera little information about entertainment. It was only a matter of time before an E-Zine would emerge spotlighting the entertainment at the casinos and around town.

Rockandrollcasino.com made its debut on September 1st. It is weekly web magazine that covers rock and roll and contemporary bands, concerts, and music in Las Vegas, Atlantic City, and other casinos around the world where rock music events are held. It was created for the 21 to 50 something rock music fan, gambling fans and locals and visitors alike to gambling destinations around the country. The site offers interviews, reviews, current news, tips and tricks, casino reviews, and other entertainment sources for the rock and roll gambler.

Las Vegas is the new entertainment capital of the world, and they bring you information about the happenings around the city. The say "Las Vegas is incubating the rock music scene in its own desert microwave. The city is exploding with bands, concerts, events and scenes. And we're happy to bring it to you."

A separate section will keep you informed about the entertainment in Atlantic City as well as other sites around the world. When an artist or group comes to a casino city they want to give you everything you need to enjoy that scene. Rock and Roll Casino.com will provide you with artist bios, CD reviews, discography, venue information, ticket info, website reviews and links, concert reviews, and whatever else they can find to help you get the most of the experience.

If you join the Fan Club you will have an opportunity to win CD's, concert tickets, gambling products, books, videos, even hotel stays in Las Vegas, Atlantic City, and other gambling destinations. You will also receive their free newsletter to keep you informed about new features on the site.

If you are looking for gambling information you will not be disappointed. On the site you will find gambling advice about what to play and how to play it. Ernie Kaufman offers his sports betting advice. They will keep updated on all the gambling and casino news from around the country as well.

The Travel and Reservation section will help you plan your next vacation to the gambling destination of your choice. Got a lame email address? Get FREE email with the "rockandrollcasino.com" domain. Sign up online.

Sports Books Have North Carolina Favored in Online Casinos

The four teams that are left in the NCAA tournament all could make a case for being the best. It is not supposed to happen that all four number one seeds from the regions advance to the final four.

That is the case this year. The North Carolina Tarheels, Memphis Tigers, Kansas Jayhawks, and UCLA Bruins, all emerged unscathed from their regions, and now have a chance at winning a national title.

The Tarheels have the best chance of bringing a title to North Carolina, according to sports books. They are listed at +160. They finished the season number one in the polls, and have been playing at a high level in the tourney.

The Memphis Tigers are the second choice. They only have one loss on the year, and if not for a last second shot by Tennessee, they could be undefeated going into their game with UCLA.

The Bruins come in as the underdog of the final four teams. They are +320. Do not let the number fool you, however. This team is as good as all of the other three, and just as capable of winning these final two games.

The Jayhawks have quietly played well in the tournament. Due to the publicity the other teams are receiving, Kansas has been a bit overlooked. Their +290 number indicates that they can also win it all.

The semi final games are on Saturday, with the national championship on Monday.

Colorado Casinos & Gambling Guide

Your source for information on the Colorado casinos in Black Hawk, Central City, Cripple Creek, Ignacio and Towaoc. We include up-to-date casino contact information for all casinos in Colorado plus we have casino pictures, casino transportation information, information on lodging and hotels near Colorado casinos and vital information you should have about Colorado gaming in general.

Colorado Casinos & Gambling

Colorado had indian gaming long before it passed a limited stakes gambling bill in 1991 that allowed limited stakes gaming ($5 maximum bet limit) in the historic gold mining towns of Blackhawk, Central City and Cripple Creek.

In the beginning everything seemed good natured about preserving the historic districts and bringing in an economy. Well there certainly is an economy there now but many will question how much history has been preserved within.

Colorado casino gambling is growing by leaps and bounds. There is fresh news about Colorado gambling everyday. There is always expansion in one of the gaming towns someway or another.

Already in 2004 we have seen the opening of two casinos in Cripple Creek – the Gold Creek Casino and the Wild Horse Casino.

There are now rumors of a new Indian Casino, first dubbed "The Cheyenne Apache Homecoming Project," moving it sights to Central City as that town begins to finish up their direct exit off of Interstate 70.

Harveys Wagon Wheel Hotel & Casino has long since become Fortune Valley Hotel & Casino.

The Isle of Capri Hotel & Casino has now purchased Colorado Central Station and is currently building a new hotel and parking garage between the two which current rumor has including a pedestrian bridge to link everything together.

The Gilpin Hotel Casino has a new face. Doc Holliday's Casino in Central City has moved to the Old Glory Hole Casino building... Never a dull moment in Colorado casinos!

Colorado Slots, Poker & Blackjack

First off if you are a poker player or blackjack, please join the Colorado Gambling Forum where we have been trying to get discussion etc... started.

There are plenty of slots to choose from in Colorado. Most are manufactured by IGT or Aristocrat machines. There is plenty of video poker, too from Jacks or Better to just about anything you want. Payback rate is pretty good, too – with perfect strategy! There are statewide progressive slots and inhouse progressives in every denomination from penny slots to five dollar slots. There are rumors of the stakes (limits) being raised sometime soon.

Live blackjack and poker tables are available in the larger casinos and some of the smaller casinos, too. There is also three card poker available with live dealers. Texas Hold'em seems to be the most common and popular poker game played in the gambling towns. The Lodge Hotel & Casino has the largest poker room in Black Hawk. The Fortune Valley Hotel & Casino has the largest blackjack / poker room in Central City. Midnight Rose has the largest in Cripple Creek to my knowledge.

Black Hawk, Colorado is the largest and most flashy of all the towns. It's historic downtown is intact but the big casinos have all but ignored the historic guidelines it seems. Naturally if you had to compare one of the three Colorado gaming towns to Vegas, Black Hawk would be it. (but all Colorado gambling is different than Vegas).

Black Hawk's largest casinos are the Isle of Capri, The Lodge, Mountain High, Mardi Gras and the Riviera. All of the other casinos more or less are housed in their original historic mining buildings left over from the gold rush or have at least kept the old west feel to their buildings.

If you drive less than one mile up the road to Central City, Colorado you'll find a great little hide-away. Central City has all the amenities of Black Hawk but no crowds. Plus Central City really is a cool place to be. Home to the Central City Opera, the Teller House and other historic places Central City is a family pleaser (over 21)....

Please make sure to visit Cripple Creek, Colorado, which is expanding quickly too. Two new casinos in Cripple Creek to start off the new year. Wild Horse & Gold Creek as mentioned above.

Online we have the birth of the Colorado Gambling Forum which finally bridges (or hopes too) the communication gap between patrons and casinos. Make sure you visit the gambling forum and signup to enter monthly prizesplay free casino games and more.

OPPORTUNITIES OFFERED BY ONLINE GAMBLING

Like combinations always win in gambling, the winning of online gambling sites tremendously are based on the combination of two hot industries – Internet and Gambling. While the first one is comparatively newer and a brain-child of scientists in technology, the latter is much older for centuries. Both have a universal application irrespective of caste, creed, color, ethnicity, language, territory and gender limitations whatsoever. The internet has made e-commerce possible through out the world and so also gambling which was confined to brick and mortar online gambling dens inside various countries.

Simply because of this universal nature of gambling, countries through their governments are scratching their heads as how to promulgate laws forbidding online gambling. However some countries like U.S., Germany and Australia have enacted laws with a view to cripple wagering on the online gambling sites by round-about methods of restricting financial transactions. These statues can only contain the citizens of these countries but here also there is a great escape for them to circumvent the enforcement of such poor-sighted enactments through offshore financial accounts. The organizers of the online gambling sites also have a variety of options to cross the barriers of curbs on them, by incorporating their establishments elsewhere in foreign countries. Thus the “forbidden apple” for these countrymen becomes theirs for the tasting, once they launch themselves into the cyber-world as players.

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The revenue loss is cited as the main reason for prohibiting online gambling by the respective governments, who are being pressurized by the barrens of the real world gambling outfits on the one side for fear of competition and the inability to track the taxation accountability of the online gambling sites owing to the vastness of the internet transactions on the other side.

As regards the gamblers are concerned online, they are least bothered about these promulgations and worries of their state governments and embark on their activities of indulgence in a plethora of online gambling sites. They are immensely pleased with the opportunities being offered by online gambling. The foremost of them is they can blissfully engage into gambling online right from the comfort of their homes; no commuting; no dressing up; no hassles of traffic jams; no waiting for a seat in their favorite game table; no jostling in the milling crowds with their annoying smells; an array of games to select from the sea of varieties offered; the warm welcome and offer of a seat in the gambling table any time and every time; a gathering of players in thousands from the nooks and corners of the universe; preference for appearing as self with introduction or in total anonymity; no entrance fees as demanded by the offline clubs and casinos; on the contrary there is offer of welcome bonus on registration as member in some websites; easy and hassle free transactions of money with secure software; modest price of tickets for betting for a long time and in different options of games; chances of playing free games and acquainting with the techniques of the intended gambling game, before risking their own money (never imaginable in a real-world casino or club) and above all fabulous prize monies through jackpots accumulated through an enormous number of players online, which is never possible in any of the offline gambling dens.